How many words could one make using the specified combination?There are 7 words available for any word that has 'io' in and ends with 'si'.
In Scrabble, what's the highest possible score possible using this list of words that have 'io' in and end with 'si'?For a score of 12 points in Scrabble, you could play 'mafiosi'.
What's the largest word you can derive from the combination specified?The largest word that's possible to construct from this list is 'ostariophysi', which consists 12 letters.