How many actual words are possible to make using the combination searched for?In total, you could make 520 words.
Which word on this page has the highest character count?'Pyopneumocholecystitis' is made up of 22 characters, and is the longest word you can make from this combination.
What's the highest score you could get in Scrabble using this list of words starting with 'py' that contain 'o'?Given there are plenty of words from which to select, your best bet is 'pyrolyze' scoring 25 points.
What is the most interesting word from this page?Dictionarypedia considers 'pyroacid' to be the most peculiar word you can put together. The dictionary defines it as "An acid obtained by sybjecting another acid to the action of heat. Cf. Pyro-.".